This can be mixed with two to four expressed cyclosporine capsules (squeeze the contents of the capsules into the entire bottle and shake well prior to applying once daily for patients with pyoderma gangrenosum). Per Shah R, Ouellette S, Khan S, Truong T, Pappert A, Wassef C. Novel topical cyclosporine as adjuvant therapy for pyoderma gangrenosum: A case series. JAAD Case Rep. 2023 Aug 20;40:67-73. PMID: 37731670;